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Modeling reveals cortical dynein-dependent fluctuations in ...

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By dl mercadante · 2021 · cited by 1 — the centrosomes are positioned in response to mechanical forces, primarily driven by the activity of motor proteins (3–7). as. 30 mitosis ...
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Manuscript submitted to Biophysical Journal1Article2Modeling reveals cortical dynein-dependent fluctuations3in bipolar spindle length4Dayna L. Mercadante1, Amity L. Manning2,*, and Sarah D. Olson3,*51Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, 100 Institute Rd, Worcester Polytechnic6Institute, Worcester, MA 01609, USA72Department of Biology and Biotechnology, Worcester Polytechnic Institute, 100 Institute Rd, Worcester Polytechnic Institute,8Worcester, MA 01609, USA93Department of Mathematical Sciences, Worcester Polytechnic Institute, 100 Institute Rd, Worcester Polytechnic Institute,10Worcester, MA 01609, USA11*Correspondence: [email protected], [email protected] Proper formation and maintenance of the mitotic spindle is required for faithful cell division. While much work13has been done to understand the roles of the key molecular components of the mitotic spindle, identifying the consequences14of force perturbations in the spindle rema...