Loading…
Title

Functional proteomics of kallikrein-related peptidases in ...

Description
By k oikonomopoulou · 2010 · cited by 30 — detection of active trypsin-like proteinases in ovarian cancer ascites fluid using abp proteomics. the abp proteomics protocol, involving the analysis of ...
/10
Full Text
Biol. Chem., Vol. 391, pp. 381–390, April 2010 • Copyright  by Walter de Gruyter • Berlin • New York. DOI 10.1515/BC.2010.0452010/314Article in press - uncorrected proofFunctional proteomics of kallikrein-related peptidasesin ovarian cancer ascites fluid*Katerina Oikonomopoulou1,2 , Ihor Batruch2,a , ChrisR. Smith3,a , Antoninus Soosaipillai 2, EleftheriosP. Diamandis2,3,b and Morley D. Hollenberg 1,b,**1 Department of Physiology and Pharmacology andDepartment of Medicine, University of Calgary, CalgaryT2N 4N1, Alberta, Canada2 Department of Pathology and Laboratory Medicine,Mount Sinai Hospital, Toronto M5T 3L9, Ontario, Canada3 Department of Clinical Biochemistry, University HealthNetwork, Toronto M5G 2C4, Ontario, Canada** Corresponding authore-mail: [email protected] peptidases (KLKs) are secreted serineproteinases with trypsin or chymotrypsin-like activity. Sev-eral family members, such as KLKs 6 and 10, are potentialovarian cancer biomarkers. Recentl...