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Controlled synthesis of linear polyamidoamino acids - mdpi

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By f ferruti · 2019 · cited by 4 — this polymerization process is slow, but has the merits of taking place ... michael addition steps of nh2 of α-amino acids with acrylamides, ...
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polymersArticleControlled Synthesis of LinearPolyamidoamino AcidsFederica Ferruti , Jenny Alongi , Amedea Manfredi , Elisabetta Ranucci * andPaolo Ferruti *Dipartimento di Chimica, Università degli Studi di Milano, via C. Golgi 19, 20133 Milano, Italy* Correspondence: [email protected] (E.R.); [email protected] (P.F.);Tel.: +39-02-50314132 (E.R.); +39-02-5031-4128 (P.F.)Received: 17 July 2019; Accepted: 6 August 2019; Published: 8 August 2019Abstract: Polyamidoamino acids (PAACs) are synthetic polymers prepared by the polyaddition ofbisacrylamides with natural α-amino acids, which in the process maintain both their chirality andtheir amphoteric nature. This polymerization process is slow, but has the merits of taking place inwater and of neither involving protection/de-protection steps nor releasing by-products. However,it leads to polydisperse polymers and, using α-amino acids mixtures, random copolymers. Thispaper presents a step-by-step polyaddition p...