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Article - cell press

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By s yaguchi · 2008 · cited by 129 — early development of animal embryos involves establishing ... cence methods for detecting hybrids in embryo whole mounts.
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Developmental CellArticleA Wnt-FoxQ2-Nodal Pathway LinksPrimary and Secondary Axis Specificationin Sea Urchin EmbryosShunsuke Yaguchi, 1, * Junko Yaguchi, 1 Robert C. Angerer, 1 and Lynne M. Angerer11National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA*Correspondence: [email protected] 10.1016/j.devcel.2007.10.012SUMMARYThe primary (animal-vegetal) (AV) and secondary(oral-aboral) (OA) axes of sea urchin embryos are es-tablished by distinct regulatory pathways. However,because experimental perturbations of AV patterningalso invariably disrupt OA patterning and radializethe embryo, these two axes must be mechanisticallylinked. Here we show that FoxQ2, which is progres-sively restricted to the animal plate during cleavagestages, provides this linkage. When AV patterningis prevented by blocking the nuclear function of b-catenin, the animal plate where FoxQ2 is expressedexpands throughout the future ectoderm, and ex-pression o...
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